Molecular Formula | C24H30N6O5S |
Molar Mass | 514.6 |
Solubility | DMSO : 12.5 mg/mL (20.47 mM; Need ultrasonic) |
Storage Condition | -20°C |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 1.637 ml | 8.187 ml | 16.375 ml |
5 mM | 0.327 ml | 1.637 ml | 3.275 ml |
10 mM | 0.164 ml | 0.819 ml | 1.637 ml |
5 mM | 0.033 ml | 0.164 ml | 0.327 ml |
biological activity | Apilimod mesylate (STA-5326 mesylate) is a potent cytokine interleukin-12 (IL-12) and interleukin-23 (IL-23) of oral inhibitors, with the potential to treat certain autoimmune and inflammatory diseases. Apilimod mesylate (STA-5326 mesylate) can inhibit IL-12, in human PBMC cells stimulated by IFN-γ/SAC, human monocytes and mouse PBMC cells, the corresponding IC50 values were 1 nM, 1 nM and 2 nM. Apilimod mesylate (STA-5326 mesylate) is also a small molecule compound with cell permeability that inhibits PIKfyve with an IC50 of 14 nM. |
Target | Value |
IL-12 (in IFN-γ/SAC-stimulated human PBMCs) | 1 nM |
IL-12 (in human monocytes) | 1 nM |
IL-12 (in mouse PBMCs) | 2 nM |
PIKfyve (Cell-free assay) | 14 nM |